Gliadorphin (also known as gluteomorphin) is an opioid peptide that is formed during digestion of gluten protein. Gluteomorphins are derived from gliadin, one of the main proteins found in gluten. It is usually broken down into amino acids by digestion enzymes. It has been hypothesized that children with autism have inflammation in GI tract, causing abnormal gut leakage of this compound. This is partly the basis for the gluten-free, casein-free diet. Abnormally high levels of gliadorphin have been found in the urine of autistic children via mass spectrometry testing. Corn, Soy and Gluten are used to make industrial adhesives. All three of these foods are capable and guilty of damaging the lining of the intestinal tract and leading to the malabsorption of calcium, iron, B complex, C, and trace minerals (e.g. zinc). This malabsorption or leaky gut syndrome contributes greatly to the ill health of the brain, immune system, and setting the stage for the action of these food-derived opioids. Both caseomorphins (derived from digestion of milk products) and gluteomorphins are morphine-like opioids that have been likened to drugs like LSD. They can be very sedating and addictive and help to explain why 75% of the calories in the standard American diet (S.A.D.) come from wheat and dairy alone. Food addiction is a very real thing, and these opioids play a huge role. Caseomorphins are formed during our attempt to digest casein, the protein that makes up 80-90% of the protein content of cow’s milk (versus 0-2% of goat’s milk). It is this same protein that can cause damage to the lower intestinal lining (duodenum) and a malabsorption syndrome similar to that seen in celiac disease, or gluten intolerance. Borden uses casein to make Elmer’s Glue. Perhaps knowing this information now, one might understand why pasta, bread and “grilled cheese” sandwiches are considered “comfort foods”.

Important in fat and cholesterol metabolism. Mild lipotropic agent that removes fats from the liver and lowers blood cholesterol. Has been found in studies to improve symptoms of polycystic ovarian syndrome (PCOS) including infertility, with significant weight loss and increased HDL “good” cholesterol. Used to prevent plaque build-up and arteriosclerosis (hardening of the arteries). Needed for hair growth and strong healthy hair. Helps maintain healthy skin. Used to prevent and treat eczema. Considered a brain food as it works with choline in brain cell nutrition. Needed, along with choline, for the formation of lecithin, a key building block of cell membranes that protects cells from oxidation and forms the protective sheath around the brain. Essential component of myelin that coats nerves and regulates nerve transmission and may help treat nerve disorders. Has helped improve nerve function in diabetics who experience pain and numbness arising from nerve degeneration. Preliminary research indicates that inositol has a calming effect and may help treat depression, panic attacks, and obsessive-compulsive disorder.

Tyramine-rich foods might interact with or alter how medications work in your body. For example, certain MAOIs, including certain antidepressants and medications for Parkinson’s disease, can cause tyramine buildup. Excessive tyramine intake may lead to a hypertensive crisis that can be fatal, according to the Mayo Clinic. A hypertensive crisis can occur when blood pressure is so high that you have a greater chance of stroke or death. If you have a poor ability to break down amines such as tyramine or histamine, you may experience allergic-type reactions to small amounts of amines. Your doctor may say that you’re “amine intolerant.” For the majority of people who are amine intolerant, tyramine’s effects are most obvious when you have excessive amounts. At high enough levels, you might experience symptoms, such as: Heart Palpitations Nausea Vomiting Migraine Headaches If you think you may be sensitive to tyramine or if you’re taking MAOIs, report any symptoms to your doctor. As a treatment for migraines, some doctors recommend trying a low-tyramine or tyramine-free diet. The diet’s effectiveness for treating migraines isn’t medically proven. If you’re sensitive to tyramine or you’re taking MAOIs, you may want to limit your intake of tyramine-rich foods and beverages to lower your chances for tyramine buildup. High-tyramine foods: Fermented foods; Sauerkraut, sourdough bread, fermented soy products like miso soup, bean curd, or tempeh (fermented “stinky” tofu) or Beers on tap or home brewed. Cured; smoked meats or fish, such as sausage or salami Aged; cheeses like cheddar, blue cheese, or gorgonzola Spoiled foods. some overripe fruits & vegetables Certain beans, such as fava or broad beans Some sauces or gravies like soy sauce, teriyaki sauce, or bouillon-based sauces Moderate-tyramine foods: Some cheeses are less tyramine-rich, including; American, Parmesan, Farmer’s, Havarti, and Brie Avocados, Anchovies, Raspberries, and Wines You may be able to have some beer or other alcoholic drinks. Be sure to check with your healthcare provider. Low- or no-tyramine foods Fresh, frozen, and canned meats, including poultry and fish, are acceptable for low-tyramine diets. Tips for limiting tyramine intake Use extra caution when selecting, storing, and preparing your food. Eat fresh produce within two days of purchase. Read all food and drink labels carefully. Avoid spoiled, aged, fermented, or pickled foods. Don’t thaw foods at room temperature. Thaw in the refrigerator or the microwave instead. Eat canned or frozen foods, including produce, meats, poultry, and fish, right after opening. Buy fresh meats, poultry, and fish and eat them the same day, or freeze them immediately. Keep in mind that cooking will not lower tyramine content. Use caution when you eat out because you don’t know how foods have been stored. The takeaway Tyramine buildup in the body has been associated with migraine headaches and life-threatening blood pressure spikes in people taking MAOI antidepressants. If you experience migraine headaches, think you may be intolerant to amines, or take MAOIs, you may want to consider a low-tyramine or tyramine-free diet. Talk to your health Care Provider first, and ask if this diet will work well with your ongoing medical treatment.