doctor06
Jul 29

Methylation

0 comments

Edited: Jul 29

Methylation is an extremely important biochemical reaction that’s happening every second in every cell of your body. On the cellular level, methylation is the process of transferring a methyl group (CH3) to a molecule, which activates the molecule so it can be used by the body. For example, attaching a methyl group to folate transforms it into the active form known as L-5-MTHF (L-methylfolate), which is the predominant form of folate found in the body and the only form that can cross the blood-brain-barrier. Likewise, adding a methyl group to homocysteine (a marker of inflammation and cardiovascular disease) converts it back into methionine, a harmless amino acid. The addition and removal of methyl groups to and from DNA are responsible for turning genes on and off. People with the MTHFR gene mutation (especially the C677T variety) can have significant reductions in methylation (even if they take plenty of folate) and may benefit from supplementing with activated folate, B12 and other methyl-supportive nutrients. When you have two copies of the MTHFR gene (homozygous) it becomes even more important to provide methylation support for your body, however, taking high doses of methylfolate can lead to over methylation. Common symptoms of too much methylation support include headaches, irritability, insomnia, runny nose, body pain, and itchy skin. L-5-methylfolate (L-5-MTHF) requires no additional metabolic steps to be used by the body, thus it is often the preferred choice for those with absorption or metabolic defects. Folinic acid (not folic acid) quickly converts to L-methylfolate as needed in the body, but is not “pre-methylated.” Folinic acid may be easier for individuals who are sensitive to methylated nutrients to tolerate than supplemental L-methylfolate.

New Posts
  • doctor06
    2 days ago

    Important in fat and cholesterol metabolism. Mild lipotropic agent that removes fats from the liver and lowers blood cholesterol. Has been found in studies to improve symptoms of polycystic ovarian syndrome (PCOS) including infertility, with significant weight loss and increased HDL “good” cholesterol. Used to prevent plaque build-up and arteriosclerosis (hardening of the arteries). Needed for hair growth and strong healthy hair. Helps maintain healthy skin. Used to prevent and treat eczema. Considered a brain food as it works with choline in brain cell nutrition. Needed, along with choline, for the formation of lecithin, a key building block of cell membranes that protects cells from oxidation and forms the protective sheath around the brain. Essential component of myelin that coats nerves and regulates nerve transmission and may help treat nerve disorders. Has helped improve nerve function in diabetics who experience pain and numbness arising from nerve degeneration. Preliminary research indicates that inositol has a calming effect and may help treat depression, panic attacks, and obsessive-compulsive disorder.
  • doctor06
    2 days ago

    Tyramine-rich foods might interact with or alter how medications work in your body. For example, certain MAOIs, including certain antidepressants and medications for Parkinson’s disease, can cause tyramine buildup. Excessive tyramine intake may lead to a hypertensive crisis that can be fatal, according to the Mayo Clinic. A hypertensive crisis can occur when blood pressure is so high that you have a greater chance of stroke or death. If you have a poor ability to break down amines such as tyramine or histamine, you may experience allergic-type reactions to small amounts of amines. Your doctor may say that you’re “amine intolerant.” For the majority of people who are amine intolerant, tyramine’s effects are most obvious when you have excessive amounts. At high enough levels, you might experience symptoms, such as: Heart Palpitations Nausea Vomiting Migraine Headaches If you think you may be sensitive to tyramine or if you’re taking MAOIs, report any symptoms to your doctor. As a treatment for migraines, some doctors recommend trying a low-tyramine or tyramine-free diet. The diet’s effectiveness for treating migraines isn’t medically proven. If you’re sensitive to tyramine or you’re taking MAOIs, you may want to limit your intake of tyramine-rich foods and beverages to lower your chances for tyramine buildup. High-tyramine foods: Fermented foods; Sauerkraut, sourdough bread, fermented soy products like miso soup, bean curd, or tempeh (fermented “stinky” tofu) or Beers on tap or home brewed. Cured; smoked meats or fish, such as sausage or salami Aged; cheeses like cheddar, blue cheese, or gorgonzola Spoiled foods. some overripe fruits & vegetables Certain beans, such as fava or broad beans Some sauces or gravies like soy sauce, teriyaki sauce, or bouillon-based sauces Moderate-tyramine foods: Some cheeses are less tyramine-rich, including; American, Parmesan, Farmer’s, Havarti, and Brie Avocados, Anchovies, Raspberries, and Wines You may be able to have some beer or other alcoholic drinks. Be sure to check with your healthcare provider. Low- or no-tyramine foods Fresh, frozen, and canned meats, including poultry and fish, are acceptable for low-tyramine diets. Tips for limiting tyramine intake Use extra caution when selecting, storing, and preparing your food. Eat fresh produce within two days of purchase. Read all food and drink labels carefully. Avoid spoiled, aged, fermented, or pickled foods. Don’t thaw foods at room temperature. Thaw in the refrigerator or the microwave instead. Eat canned or frozen foods, including produce, meats, poultry, and fish, right after opening. Buy fresh meats, poultry, and fish and eat them the same day, or freeze them immediately. Keep in mind that cooking will not lower tyramine content. Use caution when you eat out because you don’t know how foods have been stored. The takeaway Tyramine buildup in the body has been associated with migraine headaches and life-threatening blood pressure spikes in people taking MAOI antidepressants. If you experience migraine headaches, think you may be intolerant to amines, or take MAOIs, you may want to consider a low-tyramine or tyramine-free diet. Talk to your health Care Provider first, and ask if this diet will work well with your ongoing medical treatment.
  • doctor06
    2 days ago

    Mitochondria: Is a double-membrane-bound organelle found in most cells of the body. Think of it as the “engine” of each cell in our body Function: To  produce the energy currency of the cell (ATP), and to regulate cellular metabolism. When researchers at the University of Otago, New Zealand identified a way to target mitochondria with antioxidants, they looked carefully at mitochondrial free radical quenching. This led to the MitoQ® a mitochondria-targeted form of quinone (a form of CoQ10) MitoQ® penetrates and accumulates inside the mitochondria hundreds of times more effectively than all other forms of CoQ10 supplements. MitoQ® is a shortened form of the antioxidant ubiquinol (CoQ10) with the addition of an ion called Triphenylphosphonium, which gives it a positive charge. (+ Charge is the key to penetrate the mitochondrial membrane) This enables optimal absorption and interaction with the inner membrane of the mitochondria. Other CoQ10 does not have the ability to enter the mitochondria. Benefits of using MitoQ to improve the health & function of the Mitochondria reverses age-related vascular dysfunction. Findings suggest that mitochondrial- targeted antioxidants may have utility in terms of counteracting the effects of blood flow and vascular dysfunction associated with advancing age. -Reduces the effect of acute HPV (hypoxic pulmonary vasoconstriction), -may reduce pain and increase working memory of muscle tissue in fibromyalgia. -reduced the demand for insulin (likely due to the action of MitoQ to mitigate weight gain and improve liver function). -protected the high fat diet-fed rats from some features of the metabolic syndrome through its effects on muscle lipid metabolism and mitochondrial activity. -Along with other therapeutic strategies, may hold promise for improving motor function, and reducing the risk of clinical disability with aging. MitoQ® was selected for a world-leading independent research program in the USA to evaluate its effects on slowing and potentially reversing the aging process. To date, more than $50 million of research and over 350 peer-reviewed papers have been published Investigating MitoQ’s effect. (Research articles available on request)

© 2017 by Debora Chelson. Proudly created with Wix.com